Brimonidine tartrate ophthalmic solution is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of this medication in the past [see Adverse Reactions (6.1) and (6.2)]. Pharmacokinetics:   After ocular administration of a 0.2% solution, plasma concentrations peaked within 1 to 4 hours and declined with a systemic half-life of approximately 3 hours. In comparative clinical studies with timolol 0.5%, lasting up to one year, the IOP lowering effect of Brimonidine tartrate ophthalmic solution was approximately 4-6 mm Hg compared with approximately 6 mm Hg for timolol. Generic Name: brimonidine ophthalmic (bri MO ni deen off THAL mik) Brand Name: Alphagan P, Lumify, Alphagan. Symptoms of Brimonidine overdose have been reported in neonates, infants, and children receiving Brimonidine tartrate as part of medical treatment of congenital glaucoma or by accidental oral ingestion [see Use In Specific Populations (8.4)]. Eight percent of subjects were discontinued from studies due to inadequately controlled intraocular pressure, which in 30% of these patients occurred during the first month of therapy. This loss of effect appears with a variable time of onset in each patient and should be closely monitored. In solution, brimonidine tartrate ophthalmic solution 0.2% has a clear, greenish-yellow color. Adverse reactions occurring in approximately 10-30% of the subjects (in descending order): oral dryness, ocular hyperemia, burning and stinging, headache, blurring, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, and ocular pruritus. Brimonidine is a medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. Instruct patients that ocular solutions, if handled improperly or if the tip of the dispensing container contacts the eye or surrounding structures, can become contaminated by common bacteria known to cause ocular infections. Approximately 16% of patients on brimonidine tartrate ophthalmic solution discontinued from the study due to somnolence. Bradycardia; conjunctivitis; hypersensitivity; hypotension; iritis; keratoconjunctivitis sicca; lacrimation increased; miosis; nausea; skin reactions (including erythema, eyelid pruritus, rash, and vasodilation); and tachycardia. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. Brimonidine Tartrate (Bulk) 100 % Powder. Brimonidine Tartrate Ophthalmic Solution 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. Generic Alphagan P BRIMONIDINE is used to to treat open-angle glaucoma and high pressure in the eye. Apnea, bradycardia, coma, hypotension, hypothermia, hypotonia, lethargy, pallor, respiratory depression, and somnolence in infants receiving Brimonidine tartrate ophthalmic solutions. Pediatric Use:   In a well-controlled clinical study conducted in pediatric glaucoma patients (ages 2 to 7 years) the most commonly observed adverse events with brimonidine tartrate ophthalmic solution 0.2% dosed three times daily were somnolence (50% - 83% in patients ages 2 to 6 years) and decreased alertness. Add to Medicine Chest. Brimonidine tartrate was not teratogenic when given orally during gestation days 6 through 15 in rats and days 6 through 18 in rabbits. In rosacea it improves the redness. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. In these studies, dietary administration of Brimonidine tartrate at doses up to 2.5 mg/kg/day in mice and 1.0 mg/kg/day in rats achieved ~77 and 118 times, respectively, the plasma Cmax drug concentration estimated in humans treated with one drop Brimonidine tartrate ophthalmic solution 0.2% into both eyes 2 times per day. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. Learn more about this drug here. Last updated on April 1, 2020. Generic Name: Brimonidine (Ophthalmic) (bri MOE ni deen) Brand Name: Alphagan P, Lumify. Brimonidine tartrate ophthalmic solution 0.2% has not been studied in patients with hepatic or renal impairment; caution should be used in treating such patients. QOLIANA® (brimonidine tartrate ophthalmic solution), 0.15% (1.5 mg brimonidine tartrate per mL equivalent to 1 mg brimonidine free base per mL) is a relatively selective alpha-2-adrenergic agonist for ophthalmic use. This loss of effect appears with a variable time of onset in each patient and should be closely monitored. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Select one or more newsletters to continue. Each mL of Brimonidine tartrate ophthalmic solution contains the active ingredient Brimonidine tartrate 0.2% (2 mg/mL) with the inactive ingredients benzalkonium chloride 0.005% (0.05 mg/mL) as a preservative; citric acid; polyvinyl alcohol; sodium chloride; sodium citrate; and water for injection. This medicine reduces pressure by enhancing fluid drainage in the eye and also by reducing fluid formation in the eye. Brimonidine tartrate ophthalmic solution 0.2% should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. More Ways to Save. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), antihypertensives and/or cardiac glycosides is advised. Brimonidine/timolol, sold under the brand name Combigan, is a fixed-dose combination medication eye drop indicated for the treatment of glaucoma.It is a combination of brimonidine (an α 2 adrenergic … There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. PRESERVATIVE ADDED:   Benzalkonium Chloride (0.05 mg). Advise patients that if they have ocular surgery or develop an intercurrent ocular condition (e.g., trauma or infection), they should immediately seek their physician's advice concerning the continued use of the present multidose container. The recommended dose is one drop of brimonidine tartrate ophthalmic solution 0.2% in the affected eye(s) three times daily, approximately 8 hours apart. Should be instilled at least 5 minutes apart date marked on the bottle with NDC 24208-411 is a! 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